The “Thrombophilia Profile-Maxi” is an extensive panel of tests used to evaluate and diagnose various thrombophilic conditions, which are disorders that increase the risk of abnormal blood clot formation (thrombosis). The profile includes a comprehensive set of coagulation and immune-related tests to assess different factors involved in the clotting process and immune responses that can contribute to thrombotic events. The key components of the Thrombophilia Profile-Maxi include:

1. Protein C: Measures the level and activity of Protein C, a natural anticoagulant that helps regulate blood clotting. Low levels of Protein C may increase the risk of clot formation.
2. Protein S: Measures the level and activity of Protein S, another natural anticoagulant protein that assists Protein C in controlling clotting. Deficiencies in Protein S can lead to a prothrombotic state.
3. Antithrombin III (AT-III): Measures the level of AT-III, a critical inhibitor of coagulation factors. Deficiencies in AT-III can result in increased clotting tendencies.
4. Activated Protein C Resistance (APCR): Tests for resistance to activated protein C, which can indicate the presence of a genetic mutation that is associated with an increased risk of clotting.
5. Lupus Anticoagulant: Detects the presence of antibodies that interfere with the normal clotting process, leading to a tendency towards thrombosis.
6. Homocysteine: Measures the level of homocysteine, an amino acid. Elevated homocysteine levels are associated with an increased risk of blood clots.
7. Beta-2 Glycoprotein 1 (IgG / IgM): Detects antibodies against beta-2 glycoprotein 1, which may be linked to autoimmune-related clotting disorders.
8. ACA (Anticardiolipin Antibodies) (IgG / IgM): Detects anticardiolipin antibodies, which are also associated with autoimmune-mediated clotting events.

The Thrombophilia Profile-Maxi is ordered when there is suspicion of an underlying thrombophilia, recurrent blood clots, unexplained thrombotic events, or a family history of thrombosis. It provides a comprehensive assessment of various clotting factors and immune-related markers to aid in the diagnosis and management of thrombophilic conditions. Based on the test results, healthcare providers can devise personalized treatment plans to prevent or manage thrombotic events and reduce the risk of complications.