• The test is useful for the initial screening of cancer: This may include patients with suspected clinical signs and symptoms of gall bladder cancer.
• For monitoring treatment and relapse in patients with pancreatic adenocarcinoma. 
• The test may be used as a prognostic marker for survival following pancreatic or gall bladder surgery.
• To know the stage of cancer as well as the metastasis status
• The test can help detect recurrence, metastasis and residual cancer: This may even include patients with a history of cancer of other organs like breast, lung, pancreas etc.

Gall bladder is a rare form of cancer and often goes undetected due to the lack of specific signs and symptoms. Some clinical signs that may require further testing may include:

• Abdominal pain, mainly right upper abdomen.
• Abnormal abdominal bloating
• Jaundice (yellowing of eyes and skin)
• Uncontrolled loss of weight with malaise.

The other group of patients who may also require testing include:

• Patients already undergoing treatment for cancer.
• Patients who have completed the treatment to know the disease status.
• Familial history of cancers.
• Presence of high risk factors for gall bladder cancer like chronic alcoholic, smoker, high diabetic etc.