Atherosclerosis Profile 1 Test
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Atherosclerosis is the deposition of fats/cholesterol in the blood vessels leading to formation of plaques. This blocks or clogs the blood vessel leading to impaired blood supply to the vital organs of the body. Blood vessels of the heart are most commonly affected leading to coronary artery disorders. Cardiovascular disease is the top cause of death for heart attacks and strokes, in asymptomatic people. Risk factors including age, smoking status, hypertension, diabetes, cholesterol, and HDL cholesterol are used by physicians to identify individuals likely to have an ischemic event & to evaluate cardiovascular risk. The test measures the various parameters that can lead to atherosclerosis or formation of plaques.
The Atherosclerosis Profile-1 test is a comprehensive blood test that assesses the health of blood vessels, particularly those of the heart, and evaluates the risk of cardiac diseases, stroke, and peripheral vascular diseases. It measures various parameters related to cholesterol and other lipids, as well as inflammatory markers, providing a detailed picture of the risk of atherosclerotic cardiovascular disease (CVD).
This test is crucial for individuals at risk of or already experiencing symptoms of cardiovascular diseases. It helps identify early signs of atherosclerosis in asymptomatic individuals, especially those with a family history of hypercholesterolaemia or other cardiovascular risk factors such as age, smoking, hypertension, and diabetes. The Atherosclerosis Profile-1 test also aids in evaluating the effectiveness of current treatment plans for cardiovascular health.
Created by : Dr.Shibani R Medical Writer, Medical Affairs
Reasons for Undergoing the Atherosclerosis Profile-1 Test
There are several reasons why an individual may need to undergo the Atherosclerosis Profile-1 test:
- To assess the risk of heart diseases, strokes, and peripheral vascular diseases
- To diagnose potential cardiovascular issues at an early stage
- For individuals with a familial history of hypercholesterolaemia or early-stage heart disease
- For those exhibiting symptoms such as chest pain, shortness of breath, or other cardiovascular symptoms
- To monitor the effectiveness of lipid-lowering therapies
- For individuals with conditions like rheumatoid arthritis, which can increase the risk of subclinical atherosclerosis
List of Parameters Considered During the Atherosclerosis Profile-1 Test
The Atherosclerosis Profile-1 test measures several key parameters to assess cardiovascular health:
- Total Cholesterol: Indicates the overall level of cholesterol in the blood; high levels can increase the risk of heart disease.
- HDL (High-Density Lipoprotein) Cholesterol: Often referred to as “good” cholesterol, high levels of HDL are associated with a lower risk of heart disease.
- Non-HDL Cholesterol: Calculated by subtracting HDL from total cholesterol, it includes all the “bad” cholesterol and is a better predictor of heart disease risk than total cholesterol alone.
- LDL (Low-Density Lipoprotein) Cholesterol: Known as “bad” cholesterol, high levels can increase the risk of heart disease.
- VLDL (Very Low-Density Lipoprotein) Cholesterol: Another type of “bad” cholesterol; high levels are associated with increased cardiovascular risk.
- Triglycerides: A type of fat found in the blood; high levels can contribute to hardening of arteries or thickening of the artery walls.
- Lipoprotein (a) or Lp(a): Helps determine how cholesterol is transported in the body and provides insight into the risk of heart disease beyond regular cholesterol screening.
- Apolipoproteins B/A1: ApoB measures the number of LDL particles, while ApoA1 measures the number of HDL particles; the ratio of ApoB to ApoA1 is a strong indicator of cardiovascular risk.
- Lp-PLA2: A vascular-specific inflammatory biomarker that indicates the risk for atherosclerotic cardiovascular disease; high levels may suggest the need for more aggressive lipid-lowering therapy.
Atherosclerosis Profile-1 Test Preparation
To prepare for the Atherosclerosis Profile-1 test, follow these steps:
- Fast for 12-14 hours before the test, meaning you should not eat or drink during this period
- Provide your doctor with a detailed medical history and undergo a physical examination
- Inform your doctor if you have been drinking alcohol, taking niacin supplements, aspirin, or oral oestrogen hormones, as these can affect test results
Atherosclerosis Profile-1 Test Results & Interpretation
The results of the Atherosclerosis Profile-1 test are interpreted based on the following normal ranges:
- Cholesterol: Up to 200 mg/dL
- HDL: Minimum of 60 mg/dL
- Non-HDL: Maximum of 130 mg/dL
- LDL: Between 100 to 129 mg/dL (may vary if you have conditions like diabetes)
- VLDL: Between 2 to 30 mg/dL
- Triglycerides: Up to 150 mg/dL
- Lp(a): Should not exceed 30 mg/dL
- Apolipoprotein A1: Between 110 to 180 mg/dL for men and between 111 to 205 mg/dL for women
- Apolipoprotein B: Should not exceed 100 mg/dL
- Lp-PLA2: Within 200 ng/dL
High levels of LDL, VLDL, triglycerides, Lp(a), and Lp-PLA2, as well as low levels of HDL, indicate a higher risk of cardiovascular diseases. The ApoB/A1 ratio provides additional insight into cardiovascular risk, with higher ratios indicating greater risk.
Home Collection for Atherosclerosis Profile-1 Test
SimplyCare offers a convenient home sample collection service for the Atherosclerosis Profile-1 test, ensuring comfort and safety for patients. A trained phlebotomist will visit your home to collect the necessary blood samples, maintaining high standards of sample handling and testing accuracy. This service allows you to undergo the test without the need to visit a diagnostic centre, saving time and effort. With SimplyCare’s commitment to providing quality diagnostic solutions and timely, reliable results, you can trust that your Atherosclerosis Profile-1 test will be handled with the utmost care and professionalism, empowering you to take proactive steps in managing your cardiovascular health.
Price : ₹ 5245
- Atherosclerosis test is basically done to assess the status of the blood vessels of the heart and the risk of cardiac diseases, stroke, and peripheral vascular diseases. The cholesterol tests measure the levels of individual cholesterols in the blood.
- Lp (a) serum test is prescribed to understand how well the cholesterol is transported in the body. This gives a more detailed idea of the risk of heart diseases than the routine cholesterol screening and may help in early detection of potential cardiovascular problem.
- Apolipoproteins B/A is a test that can help predict cardiovascular risk in patients. It gives a more detailed idea of the risk of heart diseases than the routine cholesterol screening.
- Lp-pla2: It is a vascular-specific inflammatory biomarker providing information on risk for atherosclerotic cardiovascular disease (CVD). It is useful in cases of early stage heart diseases, family history of hypercholesterolemia and blood vessel diseases having normal triglycerides and total cholesterol levels.
The Atherosclerosis Profile-1 test is done to assess the status of the blood vessels of the heart and the risk of cardiac diseases, stroke, and peripheral vascular diseases. t includes:
- Total cholesterol test: It measures the levels of individual cholesterols.
- Lp (a) serum test: It helps to ascertain how the cholesterol is transported in the body. This gives a clearer idea of the risk of heart disease compared to regular cholesterol screening and may help diagnose potential cardiovascular issues at an early stage.
- Apolipoproteins B/A: It helps doctors to assess cardiovascular risk factors in patients. t gives a clearer idea of the risk of heart disease than regular cholesterol screening.
- Lp-pla2: It looks for the vascular-specific inflammatory biomarker, Lp-pla2, providing information on the risk for atherosclerotic cardiovascular disease (CVD). t is useful in cases of early-stage heart disease or for those with a familial history of hypercholesterolemia.
- HDL: High-density lipoprotein, also known as good cholesterol. igh levels of HDL are preferred as it flushes out other forms of harmful cholesterol.
- LDL: Low-density lipoprotein, also known as bad cholesterol. t should ideally be lower.
- Non-HDL: Removing HDL from total cholesterol gives Non-HDL values, which helps determine risk factors for heart disease.
- VLDL: High VLDL levels also point toward clogged arteries and heart conditions.
- Triglycerides: They can help assess the risk of peripheral arterial disease and can also be used to treat heart disease.
The test measures the Cholesterol-Total, HDL, Non HDL, LDL, VLDL and Triglycerides, Lp(a), Apolipoproteins B/A1, Lp-PLA2 in blood.
This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.
Maintaining lipid levels within the desirable ranges helps lower risk of heart attacks and stroke. Low HDL levels (below acceptable levels) are associated with increased risk for Atherosclerotic Cardiovascular disease (ASCVD) . High levels of Non HDL Cholesterol (above acceptable levels) are associated with increased risk for Atherosclerotic Cardiovascular disease (ASCVD). High lipoprotein (a) levels lead to cholesterol being deposited in the arterial walls which causes thickening or clogging of the arterial walls also known as “”atherosclerosis””. This disrupts the flow of blood to the heart and other vital organs. This increases the risk of heart diseases, strokes, and other peripheral arterial diseases. High B/A1 ratio increases the risk of heart diseases. Low ratio may reduce the risk of cardiac diseases and stroke. Apo-B/A1 ratio is a more specific test that gives a clearer picture of the risk of heart diseases as compared to routine cholesterol tests. High Lp- PLA2 levels may indicate need for more aggressive lipid lowering therapy to reduce the risk of CVD events. Patient with high levels are prone to rupture of plaque and associated cardiovascular events Low levels may mean that Lp- PLA2 levels are not contributing to the heart disease.
To prepare for an Atherosclerosis Profile-1 test, your doctor will likely take a medical history and perform a physical exam. You may need to fast for 12-14 hours before the test. This means you won’t be able to eat or drink during that time. our doctor will give you specific instructions on preparing for the test.
Below are the normal levels for the Atherosclerosis Profile – 1 test :
- Cholesterol: Upto 200 mg/DL
- HDL: Minimum of 60 mg/DL
- Non- HDL: Maximum of 130 mg/DL
- LDL: Between 100 to 129 mg/DL. t might vary if you have conditions like diabetes.
- VLDL: Between 2 to 30 mg/DL
- Triglycerides: Upto 150 mg/DL
- Lp(a): Should not exceed 30 mg/DL
- Apolipoprotein A1: Between 110 to 180 mg/DL for men and between 11 to 205 mg/DL for women.
- Apolipoprotein B: Should not exceed 100 mg/DL
- Lp-PLA2: Within 200 ng/DL
Atherosclerosis, or arteriosclerosis, also known as coronary heart disease (CAD), is a serious heart condition caused due to the blockage of the coronary arteries due to plaque buildup. It can lead to cardiovascular complications like heart attack and cardiac arrest without prompt treatment.
- Total Cholesterol
- HDL Cholesterol
- Non-HDL Cholesterol
- LDL Cholesterol
- VLDL Cholesterol
- Triglycerides
- Lipoprotein (a) or Lp(a)
- Apolipoproteins B/A1
- Lp-PLA2
Atherosclerosis is the deposition of fats/cholesterol in blood vessels leading to plaque formation. This blocks or clogs the blood vessel, leading to an insufficient blood supply to the body’s vital organs. Blood vessels of the heart are most commonly affected by this condition, leading to coronary artery disorders— he Atherosclerosis Profile-1 test measures up to 9 parameters that can lead to atherosclerosis or plaque formation.
