Osteoporosis Profile III Test
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Osteoporosis is a bone condition that causes reduced bone mass leading to frequent bone and joint pains, brittle bones and increased risk of fractures. Various factors apart from age, sex, and racial predisposition increase the risk of osteoporosis. The condition often goes undiagnosed till the occurrence of an injury, fracture or deformity. Hence, it is recommended to get an Osteoporosis Profile test to measure the various parameters in blood and urine that may increase the risk of osteoporosis in an individual. Many times in patients undergoing treatment for osteoporosis, the disease status needs to be evaluated. Osteoporosis III is recommended for such patients.
Osteoporosis is a condition that causes bones to become weak. It is often referred to as “the silent disease” because injuries, fractures, or deformities can go unnoticed until they cause symptoms. It is seen in men and women. But it is far more common in women. Osteoporosis usually affects bones in the spine, hip, and wrist.
Why is the osteoporosis profile III test done?
The parameters checked in your blood and urine samples help your doctor:
- Monitoring profile on Hormone replacement therapy (HRT)
- to determine your osteoporosis status and your risk of developing the condition.
- to determine bone strength and fracture risk by measuring bone turnover.
- to keep track of how well the osteoporosis medication is working.
- to evaluate upcoming osteoporosis medications in research trials.
- to diagnose bone diseases such as post-menopausal osteoporosis, bone metastasis, and Paget’s disease.
- to assess osteoporotic postmenopausal women receiving antiresorptive therapy.
The Osteoporosis Profile III Test is a comprehensive diagnostic tool designed to evaluate the health of your bones. It measures various substances in your blood and urine that are crucial for bone metabolism, providing a detailed picture of your bone health. This test is essential for the early detection and management of osteoporosis, a condition characterized by weak and brittle bones that increases the risk of fractures.
The osteoporosis test helps monitor patients on hormone replacement therapy (HRT), determine osteoporosis status, assess bone strength and fracture risk, track the effectiveness of osteoporosis medication, and diagnose bone diseases such as post-menopausal osteoporosis, bone metastasis, and Paget’s disease. It is also useful for evaluating osteoporotic postmenopausal women receiving antiresorptive therapy and individuals with high-risk factors such as family history of osteoporosis, rheumatoid arthritis, long-term steroid use, and testosterone deficiency.
Written by: Dr.Shibani R, Medical Writer, Medical Affairs
Reasons for Undergoing the Osteoporosis Profile III Test
The osteoporosis test is undertaken to monitor patients on hormone replacement therapy (HRT), determine osteoporosis status and fracture risk, assess bone strength, track osteoporosis medication effectiveness, diagnose bone diseases, and evaluate high-risk individuals with family history or certain medical conditions.
List of Parameters Considered During the Osteoporosis Profile III Test
The Osteoporosis Profile III Test measures calcium, phosphorus, alkaline phosphatase, beta 2 crosslaps (CTX-1), deoxypyridinoline (DPD), osteocalcin, 25-hydroxy vitamin D, parathyroid hormone (PTH), and estradiol (E2). These markers help identify abnormal bone metabolism levels, indicating potential bone health issues.
Osteoporosis Profile III Test Preparation
Generally, no special preparation or fasting is required for the Osteoporosis Profile III Test. A small blood sample is drawn from a vein in your arm, and the first morning urine sample (about 10 ml) is collected. Avoid biotin supplements 10–12 hours before the test.
Osteoporosis Profile III Test Results & Interpretation
The results are interpreted based on the levels of various markers measured. Abnormal levels can indicate increased bone resorption, bone loss, or other bone health issues. The test helps assess fracture risk and monitor treatment effectiveness. A healthcare professional should interpret the results and provide personalised advice.
Home Collection for Osteoporosis Profile III Test
Home collection for the Osteoporosis Profile III Test offers a convenient solution for individuals to get tested without visiting a clinic. With SimplyCare’s lab services, a trained phlebotomist will come to your home to collect blood and urine samples, ensuring high-quality care and accurate results.
Patients can expect a seamless experience with timely and reliable results, empowering them to take proactive steps in managing their bone health. SimplyCare’s commitment to accessible healthcare underscores its dedication to providing quality diagnostic solutions conveniently at home.
Price : ₹ 8,215
Osteoporosis profile test measures certain parameters in blood and urine that may aid the monitoring of osteoporosis disease status. The common symptoms are frequent non-specific backache, brittle bones leading to frequent falls and fractures, loss of height over time, bending of the spine (kyphosis). This profile test is mainly done in patients undergoing Hormone replacement therapy (HRT).
Osteoporosis profile test measures the levels of calcium, phosphorus and alkaline phosphatase in blood serum, DPD and P1Np levels in urine sample. Beta 2 Crosslaps is also measured.
It is a profile test that measures specific parameters in blood and urine. Bone ‘resorption’ markers can be measured in blood or urine. Bone ‘formation’ markers are measured in blood. This helps track the progression of osteoporosis disease.
The blood sample is taken from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes. Early morning first or second void urine sample is recommended for measuring the DPD levels.
Low calcium levels may lead to dry skin, coarse hair, brittle nails, muscle cramps, tingling, and cardiac irregularities. Low calcium levels (hypocalcemia) may occur due to hypoparathyroidism, kidney conditions, malnutrition. pancreatitis, low calcium diet and vitamin D deficiency.
High calcium levels may lead to constipation, abdominal pain, nausea, vomiting, and mental confusion. High calcium levels (hypercalcemia) may indicate hyperparathyroidism (overactive parathyroid gland), certain cancers, bone disorders like Paget’s disease or high vitamin D levels.
High phosphorus levels maybe due to kidney disorders, diabetic ketoacidosis, liver diseases, hypoparathyroidism, hypocalcemia, excess phosphorus in the diet and even due to certain medications.
Low phosphorus levels may occur due to hyperparathyroidism, hypercalcemia, lack of phosphorus in the diet, alcoholism and malnutrition.
High levels of ALP are seen in:
Children during active bone formation, pregnant women, those with hepatobiliary disease like bile duct obstruction, hyperparathyroidism, chronic kidney disease, vitamin D deficiency, rickets, osteomalacia, bacterial infection and malignant tumour.
High DPD levels in urine indicate the risk of osteoporosis due to poor bone re-absorption status.
This is most commonly seen in post menopausal women with low estrogen levels.
High P1NP levels are seen in patients with osteoporosis and Paget’s disease. Post beginning the HRT , if the levels are found to reduce it may show treatment effectiveness.
The osteoporosis profile III test is a profile test that measures the levels of:
Calcium (Ca)
Phosphorus (P)
Alkaline Phosphatase-Total (ALP-Total)
Beta 2 Crosslaps (CTX-1)
Alkaline Phosphatase-Bone Fraction
Osteocalcin
25-hydroxy Vitamin D (25-OH Vitamin D)
Parathyroid Hormone (PTH)
Estradiol (E2)
Procollagen 1 Intact N-Terminal Propeptide (P1NP)
